Chiefs will be taking part in the knockout phase for the first time in the club’s history after the Soweto giants’ successful group stage campaign.
The 2001 Caf Cup Winners’ Cup champions will fancy their chances against Simba, who are hoping to go all the way and clinch their maiden continental trophy this season.
The winner between the two teams will face either Tunisian giants Esperance or Algerian club CR Belouizdad in the semi-finals.
The quarter-final first-leg matches are scheduled to be played between 14-15 May and the second-leg encounters will then place between 21-22 May.
While the semi-final first-leg matches will be played between 18 -9 June, and the second-leg games will be played between 25-26 June.
The final of Africa’s most prestigious club permanent will then be played on 17 July 2021.
Quarter-finals fixtures in full:
- Al Ahly vs Mamelodi Sundowns
- MC Alger vs Wydad Athletic Club
- CR Belouizdad vs Esperance de Tunis
- Kaizer Chiefs vs Simba Sports Club
- Al Ahly or Mamelodi Sundowns vs CR Belouizdad or Esperance de Tunis
- MC Alger or Wydad Athletic Club vs Kaizer Chiefs or Simba Sports Club
The first-leg ties will take place between 14-15 May which will be hosted by the group runners-up before the return leg matches scheduled for 21-22 May.